Nizagara Long Last Tablet Price in Pakistan Sildenafil Citrate 142Mg Dapoxetine 30Mg For Male Erectile Dysfunction in Premature Ejaculation 

Nizagara Long Last Tablet is Very Famous And Popular in Pakistan Due To His efficacy. Result Oriented Formulation.

Pharmacokinetics Sildenafil:

The onset of action: 60 minutes
duration: 2-4 hours
Absorption: rapid, slower with a high-fat meal
Attachment to proteins in the blood: 96% Breakdown process: Liver through CYP3A4 (Major pathway) and CYP2C9 (Minor pathway)
Bioavailability: 40%
Half-life elimination: 4 Hours
Peak Performance Window: 30-120 minutes; postponed by 60 minutes following a meal high in fat.
Erectile Dysfunction in Premature Ejaculation – The Long Lost Night Tablet in Pakistan: A Component of the Physiological Erection Process

The process of erection is intricately linked to the parasympathetic nervous system, which plays a pivotal role in facilitating the release of nitric oxide (NO) within the Corpus Cavernosum of the penis. This NO molecule does not directly interact with the guanylate cyclase enzyme’s receptors. Consequently, it does not stimulate the production of cyclic guanosine monophosphate (cGMP). The absence of this stimulation results in the relaxation of smooth muscle within the corpus cavernosum, leading to vasodilation. This vasodilation, in turn, enhances the inflow of blood into the penis, culminating in an erection.

Benefits Of Nizagara Long Last Tablet

Long Last Dapoxetine 30mg Tablet exhibits a swift absorption profile following oral ingestion, with the peak plasma concentration (Tmaxx) typically observed between 1.4 and 2.0 hours post-dose. Subsequently, there is a notable decline in plasma concentration, which decreases to approximately 5% of the peak concentration, with this proportion increasing linearly with escalating doses up to 100 mg. The mean initial half-life of Dapoxetine following a single administration ranges from 0.5 to 0.8 hours, with a slight decrease to 0.4 to 0.6 hours following multiple doses over a span of 6 days. The terminal half-life of Dapoxetine is estimated to be 15 to 19 hours post-dose and 20 to 24 hours following multiple doses. It is metabolized in the liver to two primary metabolites.

Long last Tablet Sildenafil 142mg:

Sildenafil is a highly effective and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is tasked with the degradation of cGMP within the corpus cavernosum. The molecular structure of Sildenafil bears a resemblance to that of cGMP, thereby functioning as a competitive inhibitor of PDE5 in the corpus cavernosum. This interaction leads to an increased concentration of cGMP and enhanced erectile function.

Dapoxetine 30mg Tablet: 

Dapoxetine Tablets demonstrate their effectiveness through the primary mechanism of inhibiting the reuptake of serotonin. Additionally, it has been demonstrated to bind and inhibit the reuptake transporters of dopamine and norepinephrine.

Side Effects? 

Taking Dapoxetine comes with significant adverse reactions, but these were: Feeling sick to the stomach, Headaches, Loose stools, Lightheadedness.

How to Take Long Last Night Tablet? 

Consume 1 Tablet 1-2 Hours prior to sexual activity with warm water

Pack Of 2 Tablets Of Nizagara Long Long Last Rs.1200

4 Long Last Tablets Will Be Rs.2000/-PKR